What is a Pap Smear?

A Pap smear, also known as a Pap test or cervical cytology, is a screening test used to check for cervical cancer or pre-cancerous changes in the cervix. Cervical cancer is quite rare these days due to screening and HPV vaccination. During a Pap smear, a healthcare provider collects a small sample of cells, usually with a small plastic brush or a plastic "broom", from the cervix and sends the samples to a lab for microscopic examination. How the collected cells appear under a microscope will determine the results of the test. These results can fall into one of several categories, ranging from normal to various degrees of abnormal.

Understanding Abnormal Pap Smear Results

1. Atypical Squamous Cells of Undetermined Significance (ASCUS):
   - What it means: This result indicates that some cervical cells appear slightly abnormal, but it's uncertain whether these changes are benign or precancerous. These abnormalities can be cause by vaginal infections, hormonal changes, recent menstruation, menopause, and various other non-cancerous processes that temporarily alter cervical cells.
   - What to do: Most often, the next steps depend on the presence or absence of the HPV virus, as well as previous results. Often doctors recommend a repeat Pap smear in 6-12 months to see if the abnormality persists. This result is usually not a cause for immediate concern.

2. Low-Grade Squamous Intraepithelial Lesion (LSIL):
   - What it means: LSIL indicates early pre-cancerous cell changes on the cervix, which might be caused by the human papillomavirus (HPV) or other factors. Again, the next steps depend on presence of the HPV virus and previous Pap smear results. Vast majority of LSIL cells will regress to normal without the need for any treatment.
   - What to do: Follow-up typically includes colposcopy, a procedure in which the cervix is examined more closely with a special magnifying device called a colposcope. Usually, cervical biopsies are performed during the colposcopy procedure.

3. High-Grade Squamous Intraepithelial Lesion (HSIL):
   - What it means: HSIL suggests more significant cell changes and a higher likelihood of more advanced precancerous lesions.
   - What to do: A colposcopy and biopsy are usually recommended to determine the extent of the abnormalities. Treatment is frequently necessary to remove these cells. Typical treatment options consist of cryoablation (freezing of the cervix with a special tool) or a LEEP procedure (removal of the tip of the cervix with an electrode under local anesthesia). A less common surgery that is sometimes used to treat high-grade cervical dysplasia is called cervical conization, when a much larger cone-shaped portion of the cervix is excised under general anethesia.

4. Atypical Glandular Cells (AGC):
   - What it means: AGC indicates that cells from the cervical glands or endometrium are abnormal.
   - What to do: Further diagnostic tests, like a colposcopy or a cervical biopsy, will help assess the cause and severity of the abnormalities.

5. Squamous Cell Carcinoma or Adenocarcinoma:
   - What it means: These results suggest the presence of cervical cancer or pre-cancerous changes that require immediate attention.
   - What to do: Patiens with this diagnosis are referred to gynecologic cancer specialists called gynecologic oncologists, who take all the necessary steps to treat cervical cancer. Early-stage cervical cancer is highly curable and recurrence is very rare.

High-Risk HPV and Its Role

High-risk human papillomavirus (HPV) is a group of HPV types that can cause cervical cancer and other cancers, such as anal, vaginal, and oropharyngeal cancers. HPV is a common sexually transmitted infection, and most sexually active people will contract it at some point in their lives. However, the presence of high-risk HPV doesn't necessarily mean you'll develop cancer. It's essential to monitor and manage it properly through regular screenings, such as Pap smears.

The Benefits of HPV Vaccination

One of the most effective ways to prevent high-risk HPV infections and reduce the risk of related cancers is through HPV vaccination. Here are some key benefits:

1. Cancer Prevention:  HPV vaccination can protect against the most common high-risk HPV types linked to cervical and other cancers.

2. Early Vaccination:  HPV vaccines are most effective when administered before sexual activity begins. They are recommended for preteens and adolescents, usually around age 11 or 12.

3. Reduces Transmission:  By preventing HPV infection, vaccination not only protects you but also contributes to reduced transmission of the virus in the community.

4. Additional Protection:  HPV vaccines may provide protection against other HPV-related cancers and conditions.


Receiving an abnormal Pap smear result can be concerning, but it's crucial to follow up with your healthcare provider and discuss the next steps. High-risk HPV is often associated with abnormal Pap results, and managing it through regular screenings and vaccination can significantly reduce your risk of developing cervical cancer and other associated health problems. Remember, early detection, regular check-ups, and vaccination are key components of maintaining good cervical health and preventing serious complications.